Clara Belle Williams and her husband Jasper had three sons: Jasper Jr., James, and Charles. All became doctors, thanks to their pioneering mother's focus on continuing education. The three went on to found the Williams Medical Clinic in Chicago.
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Clara Belle Williams was the first black graduate of New Mexico State University. A teacher in Las Cruces, she faced discrimination during her time at the university, but persevered and completed her English degree. The NMSU English building bears her name.